Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 15/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625779 | 0.91 | AURKA (0.65) | AURKAAURKB | |
| SCHEMBL13625527 | 0.85 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL13429733 | 0.83 | ADK (0.48) | AURKAAURKB | |
| SCHEMBL13625780 | 0.83 | AURKA (0.64) | AURKAAURKBEGFR | |
| SCHEMBL735226 | 0.79 | AURKA (1.00) | AURKAAURKB | |
| SCHEMBL759339 | 0.77 | AURKA (0.89) | AURKAAURKB | |
| SCHEMBL759855 | 0.77 | AURKA (0.75) | AURKACHEK1MAP2K1AURKB | |
| SCHEMBL13430270 | 0.77 | KDR (0.40) | AURKAAURKB | |
| SCHEMBL759086 | 0.77 | AURKA (0.84) | AURKAAURKB | |
| SCHEMBL13429833 | 0.76 | AURKA (0.45) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134658-A2 | FUSED BICYCLIC PYRIMIDINE COMPOUNDS AS AURORA KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-11-05 | — | — | WO | disclosed |