Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 15/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13429733 | 0.83 | ADK (0.48) | AURKAAURKB | |
| SCHEMBL13625873 | 0.83 | AURKA (0.65) | AURKAAURKBEGFR | |
| SCHEMBL13625779 | 0.82 | AURKA (0.65) | AURKAAURKB | |
| SCHEMBL13625527 | 0.81 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL757769 | 0.79 | AURKA (1.00) | AURKAAURKB | |
| SCHEMBL13430256 | 0.78 | ADK (0.43) | AURKAAURKBKDR | |
| SCHEMBL13430258 | 0.78 | ADK (0.43) | AURKAAURKB | |
| SCHEMBL13430270 | 0.77 | KDR (0.40) | AURKAAURKBKDR | |
| SCHEMBL756778 | 0.76 | AURKA (0.74) | AURKAAURKB | |
| SCHEMBL13430238 | 0.75 | AURKA (0.56) | AURKAAURKBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134658-A2 | FUSED BICYCLIC PYRIMIDINE COMPOUNDS AS AURORA KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-11-05 | — | — | WO | disclosed |