Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 19/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625873 | 0.91 | AURKA (0.65) | AURKAAURKB | |
| SCHEMBL13625527 | 0.84 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL13429833 | 0.83 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL13625780 | 0.82 | AURKA (0.64) | AURKAAURKB | |
| SCHEMBL13429733 | 0.82 | ADK (0.48) | AURKAAURKB | |
| SCHEMBL759129 | 0.79 | AURKA (1.00) | AURKAAURKB | |
| SCHEMBL13430256 | 0.79 | ADK (0.43) | AURKAAURKB | |
| SCHEMBL759962 | 0.77 | AURKA (0.76) | AURKAAURKB | |
| SCHEMBL13430270 | 0.76 | KDR (0.40) | AURKAAURKB | |
| SCHEMBL13430258 | 0.76 | ADK (0.43) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134658-A2 | FUSED BICYCLIC PYRIMIDINE COMPOUNDS AS AURORA KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-11-05 | — | — | WO | disclosed |