Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 16/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | YES1 | P07947 | 1/20 | 0.34 |
| ▸ | FGR | P09769 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626378 | 0.91 | CCND1 (0.47) | CDK6CCND1BTKCDK4YES1 | |
| SCHEMBL13626377 | 0.90 | CDK6 (0.45) | CDK6CCND1BTKCDK4YES1 | |
| SCHEMBL13626127 | 0.88 | CCND1 (0.43) | CDK6CCND1BTKCDK4YES1 | |
| SCHEMBL13626372 | 0.87 | CCND1 (0.46) | CDK6CCND1BTKCDK4YES1 | |
| SCHEMBL1422703 | 0.84 | CDK6 (0.40) | CDK6CCND1BTKCDK4YES1 | |
| SCHEMBL13626823 | 0.82 | CCND1 (0.40) | CDK6CCND1BTKCDK4 | |
| SCHEMBL13626133 | 0.77 | BTK (0.57) | BTK | |
| SCHEMBL13626182 | 0.76 | BTK (0.48) | BTKYES1FGRTECBMX | |
| SCHEMBL1423152 | 0.76 | CDK6 (0.41) | CDK6CCND1BTKCDK4YES1 | |
| SCHEMBL13626132 | 0.75 | BTK (0.50) | BTKYES1FGRTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |