Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 2/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 16/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626372 | 0.89 | CCND1 (0.46) | CCND1CDK6BTKCDK4 | |
| SCHEMBL13626127 | 0.88 | CCND1 (0.43) | CCND1CDK6BTKCDK4 | |
| SCHEMBL13626138 | 0.85 | BTK (0.51) | BTK | |
| SCHEMBL1422433 | 0.84 | BTK (0.39) | CCND1CDK6BTKRAF1BRAF | |
| SCHEMBL13626377 | 0.84 | CDK6 (0.45) | CCND1CDK6BTKCDK4CLK2 | |
| SCHEMBL13626378 | 0.83 | CCND1 (0.47) | CCND1CDK6BTKCDK4 | |
| SCHEMBL13626188 | 0.82 | CDK6 (0.45) | CCND1CDK6BTKCDK4 | |
| SCHEMBL13626142 | 0.74 | BTK (0.54) | BTK | |
| SCHEMBL1422829 | 0.73 | CCND1 (0.40) | CCND1CDK6BTK | |
| SCHEMBL1422539 | 0.72 | BTK (0.39) | CCND1CDK6BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |