SCHEMBL13626378 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	CCND1	P24385	5/20	0.47

▸	CDK6	Q00534	4/20	0.47

▸	CDK4	P11802	3/20	0.39

▸	BTK	Q06187	14/20	0.36

▸	YES1	P07947	1/20	0.34

▸	FGR	P09769	1/20	0.34

▸	TEC	P42680	1/20	0.34

▸	BMX	P51813	1/20	0.34

▸	KCNH2	Q12809	1/20	0.34

▸	SLK	Q9H2G2	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL13626377	0.91	CDK6 (0.45)	CCND1CDK6CDK4BTKYES1
SCHEMBL13626188	0.91	CDK6 (0.45)	CCND1CDK6CDK4BTKYES1
SCHEMBL13626127	0.89	CCND1 (0.43)	CCND1CDK6CDK4BTKYES1
SCHEMBL13626372	0.89	CCND1 (0.46)	CCND1CDK6CDK4BTKYES1
SCHEMBL13626182	0.85	BTK (0.48)	BTKYES1FGRTECBMX
SCHEMBL13626823	0.83	CCND1 (0.40)	CCND1CDK6CDK4BTK
SCHEMBL1423152	0.83	CDK6 (0.41)	CCND1CDK6CDK4BTKYES1
SCHEMBL13626132	0.76	BTK (0.50)	BTKYES1FGRTECBMX
SCHEMBL13626133	0.76	BTK (0.57)	BTK
SCHEMBL13626128	0.75	BTK (0.41)	BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009137596-A1	SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS	CGI PHARMACEUTICALS, INC. (US)	2009-11-12	—	—	WO	disclosed