Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980574 | 1.00 | SRC (0.46) | SRCCYP2D6HPGDLMNAMAPK1 | |
| SCHEMBL3336638 | 0.87 | PTGS2 (0.55) | L3MBTL1 | |
| SCHEMBL241909 | 0.80 | SRC (0.56) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL28232530 | 0.80 | SRC (0.56) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL9394507 | 0.80 | SRC (0.50) | SRCCYP2D6LMNAMAPK1KMT2A | |
| SCHEMBL28232476 | 0.80 | SRC (0.56) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL1100039 | 0.80 | TRPA1 (0.42) | SRCCYP2D6HPGDLMNAKEAP1 | |
| SCHEMBL6969665 | 0.78 | SRC (0.48) | SRCCYP2D6LMNAMAPK1KMT2A | |
| SCHEMBL11183816 | 0.78 | SRC (0.48) | SRCCYP2D6LMNAMAPK1KMT2A | |
| SCHEMBL28307635 | 0.78 | SRC (0.54) | SRCCYP2D6LMNAMAPK1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138440-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-19 | — | — | WO | disclosed |