Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | YAP1 | P46937 | 1/20 | 0.34 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
| ▸ | GPX4 | P36969 | 1/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL224873 | 0.94 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2POLBHTT | |
| SCHEMBL4436959 | 0.81 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2POLBHTT | |
| SCHEMBL4446700 | 0.81 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2POLBHTT | |
| SCHEMBL16082804 | 0.73 | — | — | |
| SCHEMBL24694729 | 0.71 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2POLBHTT | |
| SCHEMBL16490225 | 0.71 | CHRNB2 (0.62) | ALDH1A1LMNAPOLBCHRNB2CHRNA3 | |
| SCHEMBL16083079 | 0.71 | — | — | |
| SCHEMBL7543479 | 0.71 | CHRNB2 (0.38) | ALDH1A1LMNACHRNB2CHRNA3CHRNA4 | |
| SCHEMBL11836780 | 0.71 | ALDH1A1 (0.57) | ALDH1A1LMNASMN1; SMN2POLBHTT | |
| SCHEMBL15336652 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612114-B2 | Such as (R)-6-{2-{ethyl[4-(2-ethylaminoethyl)benzyl]amino }-4-methoxyphenyl }-5,6,7,8-tetrahydronaphthalen-2-ol; osteoporosis; breast cancer | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |