Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21633858 | 0.89 | LMNA (0.48) | LMNARIPK1PDE4APDE4BPDE4C | |
| SCHEMBL29861491 | 0.82 | LMNA (0.43) | LMNARIPK1PDE4APDE4BPDE4C | |
| SCHEMBL1917704 | 0.80 | TAAR1 (0.56) | LMNAESR1ESR2TAAR1KDM4E | |
| SCHEMBL540784 | 0.80 | ALDH1A1 (0.42) | LMNARIPK1PDE4APDE4BPDE4C | |
| SCHEMBL6055300 | 0.80 | LMNA (0.41) | LMNARIPK1PDE4APDE4BPDE4C | |
| SCHEMBL18905454 | 0.80 | LMNA (0.41) | LMNARIPK1PDE4APDE4BPDE4C | |
| SCHEMBL9772644 | 0.78 | AOC3 (0.53) | LMNAHTR1ASMN1; SMN2AOC3 | |
| SCHEMBL2678379 | 0.78 | CYP19A1 (0.42) | LMNARIPK1PDE4APDE4BPDE4C | |
| SCHEMBL6111588 | 0.78 | KMT2A (0.41) | LMNAKMT2A | |
| SCHEMBL906150 | 0.78 | AOC3 (0.53) | KDM4EALDH1A1HTR1ACYP2C9AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142967-A1 | THERAPEUTIC PROSTAGLANDIN COMPOUNDS USED AS OCULAR HYPOTENSIVE AGENTS | ALLERGAN, INC. (US) | 2009-11-26 | — | — | WO | disclosed |