Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | CFTR | P13569 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626504 | 0.88 | NAMPT (0.51) | LMNAPKMF10NPC1RAB9A | |
| SCHEMBL13626549 | 0.88 | NAMPT (0.51) | LMNAPKMF10NPC1RAB9A | |
| SCHEMBL13626550 | 0.88 | NAMPT (0.51) | LMNAPKMF10NPC1RAB9A | |
| SCHEMBL13626567 | 0.81 | F10 (0.52) | LMNAPKMF10POLBCYP3A4 | |
| SCHEMBL13626555 | 0.79 | F10 (0.49) | LMNAF10RAB9AKDM4ENAMPT | |
| SCHEMBL13626551 | 0.78 | F10 (0.55) | F10NAMPTCFTR | |
| SCHEMBL13626540 | 0.78 | F10 (0.47) | LMNAF10NPC1RAB9AKDM4E | |
| SCHEMBL13664671 | 0.76 | F10 (0.54) | LMNAPKMF10POLBCYP3A4 | |
| SCHEMBL13626564 | 0.76 | F10 (0.54) | LMNAPKMF10POLBCYP3A4 | |
| SCHEMBL13626545 | 0.74 | F10 (0.49) | LMNAF10NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |