Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | EHMT2 | Q96KQ7 | 10/20 | 0.50 |
| ▸ | EHMT1 | Q9H9B1 | 10/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | MST1R | Q04912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1893106 | 0.88 | LTA4H (0.50) | LTA4HEHMT2EHMT1FGFR2HRH3 | |
| SCHEMBL13627282 | 0.84 | FGFR2 (0.50) | LTA4HFGFR2MET | |
| SCHEMBL14540555 | 0.83 | PDGFRB (0.45) | AXLMETKDR | |
| SCHEMBL4664589 | 0.81 | PRKCQ (0.46) | LTA4HFGFR2EGFRBTKKDR | |
| SCHEMBL4664093 | 0.79 | LTA4H (0.40) | LTA4HEHMT2FGFR2AXLMET | |
| SCHEMBL5017383 | 0.77 | LTA4H (0.49) | LTA4HEHMT2EHMT1FGFR2AXL | |
| SCHEMBL13980555 | 0.77 | EGFR (0.46) | EHMT2EHMT1FGFR2AXLMET | |
| SCHEMBL4665984 | 0.76 | MET (0.46) | AXLMETKDRKITMST1R | |
| SCHEMBL4373064 | 0.76 | FLT4 (0.62) | FGFR2AXLMETEGFRBTK | |
| SCHEMBL4664603 | 0.75 | FGFR2 (0.46) | EHMT2EHMT1FGFR2AXLMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |