Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.31 |
| ▸ | STK10 | O94804 | 1/20 | 0.31 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482834 | 1.00 | BRAF (0.34) | BRAFMCHR1MCHR2LMNAKDM4E | |
| SCHEMBL4472029 | 0.85 | BPTF (0.33) | HPGDBPTFOPRM1OPRD1OPRK1 | |
| SCHEMBL13627330 | 0.85 | BPTF (0.33) | HPGDBPTFOPRM1OPRD1OPRK1 | |
| SCHEMBL4473434 | 0.84 | EGFR (0.36) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13627343 | 0.84 | EGFR (0.36) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4482788 | 0.81 | EPHA2 (0.37) | KDM4EPDGFRB | |
| SCHEMBL13627344 | 0.81 | EPHA2 (0.37) | KDM4EPDGFRB | |
| SCHEMBL4482987 | 0.81 | EPHA2 (0.37) | KDM4EPDGFRB | |
| SCHEMBL13627345 | 0.78 | UTS2R (0.40) | LMNAALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL4488827 | 0.78 | UTS2R (0.40) | LMNAALDH1A1MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |