Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | SRC | P12931 | 6/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | ABL2 | P42684 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | GAK | O14976 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.32 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482987 | 1.00 | EPHA2 (0.37) | EPHA2KDREPHB4HTR2CSRC | |
| SCHEMBL4482788 | 1.00 | EPHA2 (0.37) | EPHA2KDREPHB4HTR2CSRC | |
| SCHEMBL4489439 | 0.87 | HTR2C (0.38) | HTR2CCNR2 | |
| SCHEMBL13627333 | 0.87 | HTR2C (0.38) | HTR2CCNR2 | |
| SCHEMBL4477909 | 0.84 | P2RX7 (0.38) | HTR2CP2RX7KDM4E | |
| SCHEMBL13627347 | 0.84 | P2RX7 (0.38) | HTR2CP2RX7KDM4E | |
| SCHEMBL4480936 | 0.84 | P2RX7 (0.38) | HTR2CP2RX7KDM4E | |
| SCHEMBL4482834 | 0.81 | BRAF (0.34) | PDGFRBKDM4E | |
| SCHEMBL13627342 | 0.81 | BRAF (0.34) | PDGFRBKDM4E | |
| SCHEMBL13627343 | 0.79 | EGFR (0.36) | HTR2CP2RX7EGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |