Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4489439 | 1.00 | HTR2C (0.38) | HTR2CCNR2SMN1; SMN2DPP4LMNA | |
| SCHEMBL13627344 | 0.87 | EPHA2 (0.37) | HTR2CCNR2 | |
| SCHEMBL4482987 | 0.87 | EPHA2 (0.37) | HTR2CCNR2 | |
| SCHEMBL4482788 | 0.87 | EPHA2 (0.37) | HTR2CCNR2 | |
| SCHEMBL4481959 | 0.83 | P2RX7 (0.39) | HTR2C | |
| SCHEMBL13627341 | 0.83 | P2RX7 (0.39) | HTR2C | |
| SCHEMBL4241541 | 0.83 | P2RX7 (0.39) | HTR2C | |
| SCHEMBL4472029 | 0.80 | BPTF (0.33) | — | |
| SCHEMBL13627330 | 0.80 | BPTF (0.33) | — | |
| SCHEMBL13270031 | 0.78 | HTR2C (0.39) | HTR2CCNR2DPP4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |