Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | RECQL | P46063 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515806 | 0.87 | NPC1 (0.67) | SMN1; SMN2ALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL14003501 | 0.85 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL28416832 | 0.83 | ALDH1A1 (0.87) | SMN1; SMN2ALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL28250804 | 0.81 | POLB (0.64) | ALDH1A1NPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL824564 | 0.80 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL19403215 | 0.80 | NPC1 (0.59) | SMN1; SMN2ALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL15196083 | 0.79 | GAA (0.59) | NPC1RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL2625585 | 0.79 | HDAC1 (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9AHDAC3 | |
| SCHEMBL29904721 | 0.79 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL463597 | 0.79 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9AHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2708534-B1 | THIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHANGHAI THEORION PHARMACEUTICAL CO LTD (CN) | 2017-07-12 | — | — | EP | disclosed |
| US-7612065-B2 | Inhibitors of c-JUN N-terminal kinases (JNK) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-03 | — | — | US | disclosed |
| US-7550499-B2 | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-23 | — | — | US | disclosed |
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | SALITURO FRANCESCO G | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | MAP3K1, JUN, MAP3K7 | SMN1; SMN2 3544/4885ALDH1A1 4310/4885RECQL 4118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.