Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628526 | 0.85 | HRH3 (0.39) | HRH3HRH4 | |
| SCHEMBL13628675 | 0.79 | MAPT (0.46) | — | |
| SCHEMBL13658798 | 0.75 | HRH3 (0.62) | HRH3HRH4 | |
| SCHEMBL15986823 | 0.73 | POLB (0.53) | HRH3HRH4LRRK2 | |
| SCHEMBL13628673 | 0.73 | ASIC3 (0.32) | HRH4 | |
| SCHEMBL16065280 | 0.70 | HRH3 (0.40) | HRH3 | |
| SCHEMBL13390779 | 0.67 | ALDH1A1 (0.52) | — | |
| SCHEMBL3658312 | 0.67 | ADORA2A (0.44) | HRH3 | |
| SCHEMBL13628538 | 0.64 | ASIC3 (0.33) | HRH4 | |
| SCHEMBL3436775 | 0.63 | LRRK2 (0.40) | HRH3HRH4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612197-B2 | Reacting a nucleophil with OH group with an electrophil to form an adduct, reacting adduct with a reagent selected from oxidizing, sulfurizing or selenizing agents to produce hydroxy protected oligonucleotide, heating to deprotect hydroxy protecting group such as 2-(2-pyridyl)aminoethoxycarbonyl | The United States of America as repesented by the Secretary of the Department of Health and Human Services (US) | 2009-11-03 | — | — | US | disclosed |