Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.36 |
| ▸ | CA2 | P00918 | 5/20 | 0.36 |
| ▸ | CA9 | Q16790 | 5/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628705 | 0.77 | NOTUM (0.30) | — | |
| SCHEMBL13628742 | 0.72 | CA12 (0.37) | CA12CA2CA9CA1LRRK2 | |
| SCHEMBL15481207 | 0.70 | ADORA2B (0.30) | — | |
| SCHEMBL13628749 | 0.68 | CA12 (0.37) | CA12CA2CA9CA1LRRK2 | |
| SCHEMBL24823802 | 0.67 | — | — | |
| SCHEMBL4782762 | 0.67 | CHRM2 (0.33) | — | |
| SCHEMBL5081607 | 0.67 | KDM4E (0.35) | — | |
| SCHEMBL31614571 | 0.66 | TSHR (0.54) | — | |
| SCHEMBL22431061 | 0.66 | — | — | |
| SCHEMBL13628700 | 0.64 | ALOX5 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |