Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628709 | 0.77 | ALOX5 (0.36) | IDO1ALDH1A1ENPP2LMNA | |
| SCHEMBL13628742 | 0.73 | CA12 (0.37) | IDO1ALDH1A1ENPP2COMTKDM4E | |
| SCHEMBL4781959 | 0.69 | ALDH1A1 (0.38) | TDP1ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL12578009 | 0.68 | TDP1 (0.67) | TDP1ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL3744556 | 0.68 | IDO1 (0.50) | IDO1ALDH1A1ENPP2COMTKDM4E | |
| SCHEMBL17269680 | 0.68 | PDE10A (0.43) | TDP1ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL5789196 | 0.67 | KDM4E (0.46) | ALDH1A1MAPTKDM4ENPC1GAA | |
| SCHEMBL3180547 | 0.67 | ALDH1A1 (0.52) | IDO1TDP1ALDH1A1ENPP2MAPT | |
| SCHEMBL10064162 | 0.66 | TDP1 (0.62) | TDP1ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL21929982 | 0.66 | TDP1 (0.62) | TDP1ALDH1A1MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |