Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 12/20 | 0.41 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1102069 | 0.92 | SCN3A (0.55) | SCN3AMEN1KMT2ASCN9AMGAT2 | |
| SCHEMBL9972209 | 0.86 | SCN3A (0.57) | SCN3AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13637929 | 0.84 | SCN3A (0.41) | SCN3AMEN1KMT2ANPY5RALDH1A1 | |
| SCHEMBL1102024 | 0.82 | MEN1 (0.64) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL9972260 | 0.81 | MEN1 (0.54) | SCN3AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1102115 | 0.79 | CHRM2 (0.52) | SCN3AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1102139 | 0.78 | LMNA (0.57) | SCN3AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1102023 | 0.77 | KMT2A (0.57) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL9972210 | 0.76 | AVPR2 (0.57) | SCN3AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13828035 | 0.75 | PKM (0.63) | SCN3AMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615563-B2 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED | 2009-11-10 | — | — | US | disclosed |