Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13629587 | 0.84 | SCN3A (0.57) | SCN3AMAPK1KMT2AALDH1A1MEN1 | |
| SCHEMBL13637814 | 0.83 | MEN1 (0.55) | MAPK1L3MBTL1KMT2AALDH1A1MEN1 | |
| SCHEMBL1102069 | 0.76 | SCN3A (0.55) | SCN3AKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL9972209 | 0.72 | SCN3A (0.57) | SCN3AKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL9972260 | 0.67 | MEN1 (0.54) | SCN3AKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL1102024 | 0.66 | MEN1 (0.64) | MAPK1L3MBTL1KMT2AALDH1A1MEN1 | |
| SCHEMBL1102139 | 0.64 | LMNA (0.57) | SCN3AKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL5118232 | 0.64 | NOTUM (0.54) | MAPK1L3MBTL1ALDH1A1MAPTNPY5R | |
| SCHEMBL10201439 | 0.63 | CYP1A2 (0.48) | ALDH1A1RAB9AALOX5ARATM | |
| SCHEMBL1102115 | 0.63 | CHRM2 (0.52) | SCN3AMAPK1L3MBTL1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615563-B2 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED | 2009-11-10 | — | — | US | disclosed |