Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606075 | 0.85 | L3MBTL1 (0.51) | ALDH1A1SMN1; SMN2NPC1MAPTITGB3 | |
| SCHEMBL14314281 | 0.83 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2OPRM1OPRK1TSHR | |
| SCHEMBL14609787 | 0.81 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2OPRM1OPRK1NPC1 | |
| SCHEMBL12436953 | 0.80 | EPHX2 (0.50) | ALDH1A1NPC1GAA | |
| SCHEMBL12436034 | 0.80 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2NPC1MAPTPOLB | |
| SCHEMBL5569408 | 0.80 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2OPRM1OPRK1NPC1 | |
| SCHEMBL2606053 | 0.80 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2NPC1KDM4EKMT2A | |
| SCHEMBL24457510 | 0.79 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2OPRM1OPRK1MAPT | |
| SCHEMBL21429965 | 0.78 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2OPRM1OPRK1NPC1 | |
| SCHEMBL2687834 | 0.78 | GNAI3 (0.53) | ALDH1A1SMN1; SMN2OPRM1OPRK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |