Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5534468 | 0.88 | HTR3E (0.58) | MEN1KMT2APOLBMAPTSIGMAR1 | |
| SCHEMBL1085867 | 0.84 | MEN1 (0.71) | MEN1KMT2APOLBMTNR1BMTNR1A | |
| SCHEMBL26186649 | 0.82 | EGFR (0.59) | MEN1KMT2APOLBMAPK1MAPT | |
| SCHEMBL13302353 | 0.82 | MEN1 (0.69) | MEN1KMT2APOLBMTNR1BMTNR1A | |
| SCHEMBL1921496 | 0.80 | MTNR1B (0.72) | MEN1KMT2APOLBMTNR1BMTNR1A | |
| SCHEMBL30080139 | 0.78 | MTNR1B (0.65) | MEN1KMT2APOLBMTNR1BMTNR1A | |
| SCHEMBL8966246 | 0.78 | ALDH1A1 (0.67) | MEN1KMT2AMAPK1MAPTGAA | |
| SCHEMBL917608 | 0.78 | MTNR1B (0.65) | MEN1KMT2APOLBMTNR1BMTNR1A | |
| SCHEMBL14169345 | 0.77 | PIK3CG (0.67) | MEN1KMT2AMAPK1EGFRNPC1 | |
| SCHEMBL9479511 | 0.77 | MTNR1B (0.68) | MEN1KMT2APOLBMTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275070-A1 | Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators | HOUSEY GERARD M | 2009-11-05 | — | — | US | disclosed |