Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12282776 | 0.86 | MAPT (0.47) | NCF1LOXL2AAK1NPC1MAPT | |
| SCHEMBL15576290 | 0.83 | NCF1 (0.43) | NCF1LOXL2AAK1HTR1AADRA1D | |
| SCHEMBL20045399 | 0.81 | KMT2A (0.51) | IDO1 | |
| SCHEMBL25827570 | 0.80 | LOXL2 (0.42) | NCF1LOXL2AAK1HTR1AADRA1D | |
| SCHEMBL27558240 | 0.80 | ADRB1 (0.47) | NCF1LOXL2AAK1TP53SMN1; SMN2 | |
| SCHEMBL7510055 | 0.78 | LOXL2 (0.40) | NCF1LOXL2AAK1MAPTHTR1A | |
| SCHEMBL25823363 | 0.78 | MCHR1 (0.42) | LOXL2AAK1 | |
| SCHEMBL828159 | 0.77 | GAK (0.55) | NCF1LOXL2SMN1; SMN2GAKRIPK2 | |
| SCHEMBL23716952 | 0.77 | IDO1 (0.39) | LOXL2AAK1MAPTSMN1; SMN2IDO1 | |
| SCHEMBL30614551 | 0.76 | TLR8 (0.49) | NCF1LOXL2AAK1ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119702-A1 | AMIDE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |