Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3572910 | 1.00 | KCNH2 (0.46) | KCNH2MTNR1AMTNR1BSIRT2 | |
| SCHEMBL13638251 | 0.88 | MTNR1A (0.43) | KCNH2MTNR1AMTNR1BSIRT2 | |
| SCHEMBL3572912 | 0.87 | MTNR1A (0.38) | KCNH2MTNR1AMTNR1B | |
| SCHEMBL13407409 | 0.80 | KCNH2 (0.44) | KCNH2MTNR1AMTNR1B | |
| SCHEMBL3574972 | 0.80 | KCNH2 (0.44) | KCNH2MTNR1AMTNR1B | |
| SCHEMBL6102949 | 0.78 | KCNH2 (0.39) | KCNH2MTNR1AMTNR1BSIRT2 | |
| SCHEMBL14341402 | 0.76 | KCNH2 (0.68) | KCNH2 | |
| SCHEMBL20679509 | 0.76 | MTNR1A (0.43) | KCNH2MTNR1AMTNR1B | |
| SCHEMBL6195137 | 0.74 | KCNH2 (0.46) | KCNH2MTNR1AMTNR1B | |
| SCHEMBL3582737 | 0.73 | KCNH2 (0.54) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622481-B2 | Antibacterial compounds | GLAXO GROUP LIMITED (GB) | 2009-11-24 | — | — | US | disclosed |
| EP-1537123-B1 | AMINO-SUBSTITUTED CYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | GLAXO GROUP LTD (GB) | 2009-04-29 | — | — | EP | disclosed |