Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | APOB | P04114 | 1/20 | 0.32 |
| ▸ | MTTP | P55157 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922404 | 0.89 | LMNA (0.39) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9922385 | 0.89 | KMT2A (0.38) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9922366 | 0.84 | KMT2A (0.38) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9922383 | 0.83 | KMT2A (0.41) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9922958 | 0.82 | PTGER3 (0.42) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL14228358 | 0.82 | KMT2A (0.39) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9922396 | 0.82 | KMT2A (0.38) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9922388 | 0.82 | CA2 (0.42) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9922175 | 0.81 | KMT2A (0.38) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13638607 | 0.81 | MEN1 (0.42) | LMNAALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |