Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 11/20 | 0.67 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.65 |
| ▸ | RELA | Q04206 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.65 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.60 |
| ▸ | CKS1B | P61024 | 2/20 | 0.57 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17897816 | 0.87 | SLC40A1 (0.79) | SLC40A1NFKBIARELAMEN1KMT2A | |
| SCHEMBL13633861 | 0.87 | SLC40A1 (0.73) | SLC40A1NFKBIARELAMEN1KMT2A | |
| SCHEMBL4489851 | 0.84 | MEN1 (0.84) | SLC40A1NFKBIARELAMEN1KMT2A | |
| SCHEMBL11997103 | 0.83 | SLC40A1 (0.79) | SLC40A1NFKBIARELAMEN1KMT2A | |
| SCHEMBL4489024 | 0.83 | SLC40A1 (0.77) | SLC40A1NFKBIARELAMEN1KMT2A | |
| SCHEMBL30854819 | 0.82 | CXCR2 (0.77) | SLC40A1NFKBIARELAMEN1KMT2A | |
| SCHEMBL29255671 | 0.82 | CXCR2 (0.77) | SLC40A1NFKBIARELAMEN1KMT2A | |
| SCHEMBL11973232 | 0.80 | SLC40A1 (1.00) | SLC40A1NFKBIARELAMEN1KMT2A | |
| SCHEMBL4484000 | 0.80 | SLC40A1 (0.76) | SLC40A1NFKBIARELAMEN1KMT2A | |
| SCHEMBL11973706 | 0.79 | SLC40A1 (0.78) | SLC40A1NFKBIARELAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PDE4B, PDE7B, PDE4A | SLC40A1 4638/4885NFKBIA 980/4885RELA 4160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.