Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
| ▸ | APOB | P04114 | 1/20 | 0.33 |
| ▸ | MTTP | P55157 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922404 | 0.89 | LMNA (0.39) | LMNAMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL9923252 | 0.88 | KMT2A (0.39) | LMNAMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL9922832 | 0.88 | KCNH2 (0.37) | LMNAMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL9922372 | 0.88 | MEN1 (0.40) | LMNAMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL9922609 | 0.88 | KCNH2 (0.38) | LMNAMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL12161567 | 0.87 | MEN1 (0.38) | LMNAMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL9922184 | 0.87 | MEN1 (0.40) | LMNAMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL9923251 | 0.86 | RORC (0.37) | LMNAMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL9923249 | 0.86 | RORC (0.37) | LMNAMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL12161571 | 0.86 | MEN1 (0.38) | LMNAMEN1ALDH1A1KMT2ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |