Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKBIA | P25963 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.67 |
| ▸ | MMP2 | P08253 | 2/20 | 0.65 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | GLA | P06280 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7190921 | 0.80 | GLO1 (1.00) | NFKBIARELAGLO1MMP2SLC40A1 | |
| SCHEMBL13633824 | 0.80 | SLC40A1 (0.68) | NFKBIARELASLC40A1KDM4EALDH1A1 | |
| SCHEMBL13633842 | 0.80 | NFKBIA (0.68) | NFKBIARELASLC40A1KDM4EALDH1A1 | |
| SCHEMBL30854814 | 0.79 | SLC40A1 (0.71) | MMP2SLC40A1ALDH1A1KMT2AMEN1 | |
| SCHEMBL29255662 | 0.79 | SLC40A1 (0.71) | MMP2SLC40A1ALDH1A1KMT2AMEN1 | |
| SCHEMBL11972869 | 0.79 | SLC40A1 (1.00) | NFKBIAGLO1MMP2SLC40A1ALDH1A1 | |
| SCHEMBL13633878 | 0.78 | SLC40A1 (0.59) | NFKBIARELASLC40A1KMT2AMEN1 | |
| SCHEMBL13633916 | 0.77 | SLC40A1 (0.72) | NFKBIARELAGLO1MMP2SLC40A1 | |
| SCHEMBL13633768 | 0.77 | SLC40A1 (0.61) | NFKBIARELASLC40A1KDM4EALDH1A1 | |
| SCHEMBL13633852 | 0.77 | SLC40A1 (0.67) | NFKBIARELAGLO1MMP2SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PDE4B, PDE7B, PDE4A | NFKBIA 980/4885RELA 4160/4885GLO1 865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.