Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 5/20 | 0.70 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.64 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CCKBR | P32239 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | CCNH | P51946 | 2/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633888 | 0.91 | GABRA1 (0.67) | PFKFB3GABRA1PFKFB4MAPTCCKBR | |
| SCHEMBL788220 | 0.82 | PFKFB3 (1.00) | PFKFB3GABRA1PFKFB4CCKBRMMP8 | |
| SCHEMBL13633919 | 0.82 | GABRA1 (0.72) | PFKFB3GABRA1PFKFB4MAPTCCKBR | |
| SCHEMBL12335543 | 0.80 | GABRA1 (0.70) | PFKFB3GABRA1PFKFB4CCKBRKMT2A | |
| SCHEMBL12334565 | 0.80 | GABRA1 (0.68) | PFKFB3GABRA1PFKFB4CCKBRKMT2A | |
| SCHEMBL793435 | 0.78 | PFKFB4 (0.73) | PFKFB3GABRA1PFKFB4CCKBRMMP8 | |
| SCHEMBL21857101 | 0.78 | PFKFB4 (1.00) | PFKFB3GABRA1PFKFB4 | |
| SCHEMBL2825468 | 0.77 | PFKFB3 (0.83) | PFKFB3GABRA1PFKFB4MAPTCCKBR | |
| SCHEMBL8280458 | 0.76 | GABRA1 (0.77) | PFKFB3GABRA1PFKFB4MAPTCCKBR | |
| SCHEMBL13211036 | 0.76 | GABRA1 (0.69) | PFKFB3GABRA1PFKFB4CCKBRCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PDE4B, PDE7B, PDE4A | PFKFB3 2356/4885GABRA1 2865/4885PFKFB4 1821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.