Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.36 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638947 | 0.93 | IRAK4 (0.42) | IRAK4NTRK1FLT3NAPEPLDP2RX7 | |
| SCHEMBL13270595 | 0.85 | IRAK4 (0.44) | IRAK4NTRK1NAPEPLDP2RX7MCHR1 | |
| SCHEMBL13634551 | 0.84 | IRAK4 (0.47) | IRAK4NAPEPLDP2RX7MCHR1 | |
| SCHEMBL13634550 | 0.78 | IRAK4 (0.46) | IRAK4P2RX7MCHR1 | |
| SCHEMBL13270421 | 0.78 | IRAK4 (0.45) | IRAK4FLT3TYRO3MERTKGAS6 | |
| SCHEMBL13634739 | 0.74 | IRAK4 (0.48) | IRAK4NAPEPLD | |
| SCHEMBL13270469 | 0.73 | IRAK4 (0.47) | IRAK4 | |
| SCHEMBL13634629 | 0.73 | GRM2 (0.40) | IRAK4S1PR1FLT3TYRO3MERTK | |
| SCHEMBL13634779 | 0.72 | MCHR1 (0.43) | IRAK4MCHR1 | |
| SCHEMBL13638815 | 0.72 | MCHR1 (0.43) | IRAK4MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |