Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634853 | 0.89 | HDAC8 (0.42) | HDAC8HDAC6HDAC1S1PR1PIM1 | |
| SCHEMBL13162967 | 0.88 | HDAC8 (0.50) | HDAC8HDAC6HDAC1S1PR1SIGMAR1 | |
| SCHEMBL13634771 | 0.87 | S1PR1 (0.49) | HDAC8HDAC6HDAC1S1PR1SIGMAR1 | |
| SCHEMBL13634649 | 0.87 | S1PR1 (0.42) | HDAC8HDAC6HDAC1S1PR1PIM1 | |
| SCHEMBL13270431 | 0.81 | S1PR1 (0.38) | HDAC8HDAC6HDAC1S1PR1PIM1 | |
| SCHEMBL15888674 | 0.81 | S1PR1 (0.38) | HDAC8HDAC6HDAC1S1PR1PIM1 | |
| SCHEMBL13638887 | 0.80 | S1PR1 (0.47) | HDAC8HDAC6HDAC1S1PR1IRAK4 | |
| SCHEMBL13270753 | 0.80 | HDAC8 (0.54) | HDAC8HDAC6HDAC1S1PR1MCHR1 | |
| SCHEMBL13634841 | 0.80 | S1PR1 (0.49) | HDAC8HDAC6HDAC1S1PR1IRAK4 | |
| SCHEMBL13163118 | 0.79 | HDAC8 (0.53) | HDAC8HDAC6HDAC1S1PR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |