Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634784 | 0.91 | IRAK4 (0.51) | IRAK4MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL13270468 | 0.91 | IRAK4 (0.46) | IRAK4AKT1MAPTALDH1A1MAPK1 | |
| SCHEMBL13634739 | 0.88 | IRAK4 (0.48) | IRAK4MAPTALDH1A1KDM4EGAA | |
| SCHEMBL13634721 | 0.88 | IRAK4 (0.49) | IRAK4AKT1MAPTALDH1A1MAPK1 | |
| SCHEMBL13634551 | 0.86 | IRAK4 (0.47) | IRAK4KDM4E | |
| SCHEMBL13634943 | 0.83 | GRM2 (0.42) | IRAK4MAPTMAPK1LMNA | |
| SCHEMBL13270469 | 0.81 | IRAK4 (0.47) | IRAK4 | |
| SCHEMBL13162062 | 0.80 | IRAK4 (0.43) | IRAK4MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL13634699 | 0.78 | IRAK4 (0.50) | IRAK4MAPTABCB1ABCG2 | |
| SCHEMBL13270595 | 0.78 | IRAK4 (0.44) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |