Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418540 | 0.86 | HTR3A (0.36) | SMN1; SMN2LMNAHTR3AMEN1KMT2A | |
| SCHEMBL4425571 | 0.86 | RXFP1 (0.36) | SMN1; SMN2LMNAHTR3AMEN1KMT2A | |
| SCHEMBL4425764 | 0.84 | TP53 (0.45) | SMN1; SMN2LMNAMEN1KMT2ARXFP1 | |
| SCHEMBL4417113 | 0.76 | KDM4E (0.53) | SMN1; SMN2LMNAHTR3AMEN1KMT2A | |
| SCHEMBL4252448 | 0.75 | SMN1; SMN2 (0.66) | SMN1; SMN2LMNAHTR3AMEN1KMT2A | |
| SCHEMBL12768215 | 0.74 | KDM4E (0.40) | SMN1; SMN2LMNAHTR3AMEN1KMT2A | |
| SCHEMBL20401146 | 0.72 | PTGES (0.48) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL14525736 | 0.71 | ALDH1A1 (0.42) | SMN1; SMN2LMNAHTR3AMEN1KMT2A | |
| SCHEMBL2643233 | 0.70 | PTGES (0.63) | LTB4R2 | |
| SCHEMBL4253105 | 0.70 | ALDH1A1 (0.62) | SMN1; SMN2LMNAHTR3AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1668002-B1 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | PORTOLA PHARM INC (US) | 2009-11-11 | — | — | EP | disclosed |