Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | ALB | P02768 | 2/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634789 | 0.94 | JAK2 (0.37) | JAK2JAK1GRM2PIK3CACHEK1 | |
| SCHEMBL13638877 | 0.92 | KMT2A (0.38) | JAK2JAK1GRM2PIK3CACHEK1 | |
| SCHEMBL13638782 | 0.92 | JAK2 (0.36) | JAK2JAK1GRM2PIK3CACHEK1 | |
| SCHEMBL13634678 | 0.91 | JAK2 (0.35) | JAK2JAK1GRM2PIK3CAIRAK4 | |
| SCHEMBL13270467 | 0.91 | PIK3CA (0.34) | JAK2JAK1PIK3CACHEK1IRAK4 | |
| SCHEMBL13634942 | 0.86 | JAK2 (0.39) | JAK2JAK1GRM2PIK3CAIRAK4 | |
| SCHEMBL13638907 | 0.84 | NAPEPLD (0.37) | JAK2JAK1GRM2IRAK4PDE1B | |
| SCHEMBL13634937 | 0.82 | IRAK4 (0.50) | IRAK4 | |
| SCHEMBL13638769 | 0.81 | KMT2A (0.37) | JAK2JAK1GRM2CHEK1IRAK4 | |
| SCHEMBL13638772 | 0.81 | KMT2A (0.37) | JAK2JAK1GRM2CHEK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206707-B1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |