Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | KHK | P50053 | 3/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13011465 | 1.00 | KDM2B (0.44) | KDM2BKDM4EHTR6ALDH1A1HPGD | |
| SCHEMBL13061916 | 0.92 | KDM4E (0.46) | KDM2BKDM4EHTR6ALDH1A1HPGD | |
| SCHEMBL13011488 | 0.86 | KIF11 (0.44) | HTR6ALDH1A1PARP1PTGER4 | |
| SCHEMBL13011487 | 0.86 | KIF11 (0.44) | HTR6ALDH1A1PARP1PTGER4 | |
| SCHEMBL13011766 | 0.84 | HTR2B (0.46) | HTR6SLC6A3 | |
| SCHEMBL13011750 | 0.84 | HTR2B (0.46) | HTR6SLC6A3 | |
| SCHEMBL23697539 | 0.82 | HTR6 (0.49) | HTR6KHKSLC6A4 | |
| SCHEMBL23697542 | 0.82 | HTR6 (0.49) | HTR6KHKSLC6A4 | |
| SCHEMBL13061928 | 0.82 | L3MBTL1 (0.51) | KDM4EALDH1A1HPGDPARP1 | |
| SCHEMBL13011348 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1HPGDPARP1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119704-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |