Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | FABP4 | P15090 | 3/20 | 0.54 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | FABP3 | P05413 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803334 | 0.83 | ALDH1A1 (0.62) | PARP1HPGDALDH1A1FABP4FABP5 | |
| SCHEMBL13011509 | 0.83 | CNR2 (0.60) | PARP1HPGDALDH1A1FABP4FABP5 | |
| SCHEMBL7407425 | 0.80 | FABP4 (0.56) | HPGDFABP4FABP5KDM4ESYK | |
| SCHEMBL27722947 | 0.80 | ALDH1A1 (0.65) | PARP1HPGDALDH1A1KDM4E | |
| SCHEMBL13011471 | 0.80 | ALDH1A1 (0.61) | PARP1HPGDALDH1A1FABP4FABP5 | |
| SCHEMBL14292119 | 0.79 | ALDH1A1 (0.56) | PARP1HPGDALDH1A1FABP4FABP5 | |
| SCHEMBL13011475 | 0.78 | PTGER4 (0.58) | PARP1HPGDALDH1A1FABP4FABP5 | |
| SCHEMBL13011140 | 0.78 | ALDH1A1 (0.56) | PARP1HPGDALDH1A1FABP4FABP5 | |
| SCHEMBL28039674 | 0.78 | CYP19A1 (0.64) | PARP1HPGDALDH1A1FABP4KDM4E | |
| SCHEMBL13011521 | 0.77 | ALDH1A1 (0.62) | PARP1HPGDALDH1A1FABP4FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119704-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |