Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27175650 | 0.92 | CNR2 (0.70) | CNR2ALDH1A1HPGDCYP2D6KDM4E | |
| SCHEMBL13011524 | 0.86 | CNR2 (0.57) | CNR2CYP2D6PTGER4PSEN1PSEN2 | |
| SCHEMBL26966715 | 0.84 | CYP2D6 (0.65) | CNR2ALDH1A1HPGDPARP1CYP2D6 | |
| SCHEMBL13061930 | 0.83 | CNR2 (0.54) | CNR2ALDH1A1HPGDPARP1CYP2D6 | |
| SCHEMBL13635125 | 0.83 | PARP1 (0.61) | CNR2ALDH1A1HPGDPARP1KDM4E | |
| SCHEMBL13011521 | 0.82 | ALDH1A1 (0.62) | CNR2ALDH1A1HPGDPARP1KDM4E | |
| SCHEMBL541688 | 0.82 | CYP2D6 (0.74) | CNR2ALDH1A1CYP2D6FABP4FABP5 | |
| SCHEMBL29907915 | 0.82 | CYP2D6 (0.74) | CNR2ALDH1A1CYP2D6FABP4FABP5 | |
| SCHEMBL8803334 | 0.80 | ALDH1A1 (0.62) | CNR2ALDH1A1HPGDPARP1KDM4E | |
| SCHEMBL27722947 | 0.79 | ALDH1A1 (0.65) | ALDH1A1HPGDPARP1KDM4EPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324017-A1 | ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-12-23 | — | — | US | disclosed |
| US-20100324017-A1 | ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2119704-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324017-A1 | ACYLGUANIDINE DERIVATIVE | HTR5A, GRM5, HTR1E | CNR2 681/4885ALDH1A1 2104/4885HPGD 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.