Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966489 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2HSD11B1XIAPBIRC2KDM4E | |
| SCHEMBL6178948 | 0.72 | HSD11B1 (0.45) | SMN1; SMN2HSD11B1XIAPBIRC2RAB9A | |
| Acetic Acid SCHEMBL9331079 | 0.71 | PGK1 (0.39) | SMN1; SMN2HSD11B1KDM4ELMNAHPGD | |
| SCHEMBL13715494 | 0.71 | KDM4E (0.57) | SMN1; SMN2HSD11B1XIAPBIRC2KDM4E | |
| SCHEMBL4273303 | 0.69 | PGK1 (0.41) | SMN1; SMN2HSD11B1KDM4ELMNAHPGD | |
| SCHEMBL29860803 | 0.69 | PGK1 (0.41) | SMN1; SMN2HSD11B1KDM4ELMNAHPGD | |
| SCHEMBL7040751 | 0.68 | CACNA1C (0.46) | SMN1; SMN2HSD11B1MAPK8 | |
| SCHEMBL25832634 | 0.68 | SMN1; SMN2 (0.57) | SMN1; SMN2XIAPBIRC2RAB9AMAPK8 | |
| SCHEMBL8373697 | 0.67 | ALDH1A1 (0.42) | HSD11B1KDM4ELMNAALDH1A1 | |
| SCHEMBL8373694 | 0.67 | ALDH1A1 (0.42) | HSD11B1KDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893609-B1 | N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES | PFIZER (US) | 2009-11-18 | — | — | EP | disclosed |