Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374541 | 0.81 | MAPK14 (0.52) | KDM4EHSD17B10CA1CA2ALDH1A1 | |
| SCHEMBL8162236 | 0.74 | ALDH1A1 (0.60) | CCR6HKDC1MGLLHSD17B10IDH1 | |
| SCHEMBL1928912 | 0.74 | TSHR (0.67) | CCR6HKDC1MGLLHSD17B10IDH1 | |
| SCHEMBL3524455 | 0.73 | FGFR1 (0.50) | KDM4EHSD17B10CA1CA2ALDH1A1 | |
| SCHEMBL6261633 | 0.70 | CYP4A11 (0.60) | CCR6HKDC1MGLLHSD17B10IDH1 | |
| SCHEMBL6377479 | 0.69 | FGFR1 (0.55) | KDM4EHSD17B10CA1CA2ALDH1A1 | |
| SCHEMBL4381612 | 0.68 | MAPK14 (0.53) | — | |
| SCHEMBL6255832 | 0.68 | HSP90AA1 (0.52) | CCR6HKDC1KDM4EMGLLHSD17B10 | |
| SCHEMBL27989333 | 0.68 | LMNA (0.51) | KDM4ECA1CA2ALDH1A1SMN1; SMN2 | |
| SCHEMBL70185 | 0.68 | CYP4A11 (0.75) | CCR6HKDC1KDM4EMGLLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |