Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.50 |
| ▸ | CCND1 | P24385 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 5/20 | 0.50 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | CCND3 | P30281 | 4/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2871126 | 0.81 | KDR (0.50) | CDK4CCNA2CCND1CDK2KDR | |
| SCHEMBL2861482 | 0.81 | CDK4 (0.48) | CDK4CCNA2CCND1CDK2KDR | |
| SCHEMBL2864790 | 0.80 | CDK2 (0.49) | CDK4CCNA2CCND1CDK2KDR | |
| SCHEMBL13636075 | 0.80 | CDK4 (0.47) | CDK4CCNA2CCND1CDK2KDR | |
| SCHEMBL2865609 | 0.76 | CDK4 (0.46) | CDK4CCNA2CCND1CDK2KDR | |
| SCHEMBL4329101 | 0.75 | CDK4 (0.41) | CDK4CCNA2CCND1CDK2KDR | |
| SCHEMBL2864594 | 0.74 | KDR (0.47) | CDK4CCNA2CCND1CDK2KDR | |
| SCHEMBL2864750 | 0.74 | CDK2 (0.43) | CDK4CCNA2CCND1CDK2KDR | |
| SCHEMBL6545212 | 0.74 | CDK4 (0.44) | CDK4CCNA2CCND1CDK2KDR | |
| SCHEMBL4343373 | 0.74 | ROCK2 (0.40) | CDK4CCNA2CCND1CDK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |