Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635937 | 0.85 | MAPK10 (0.40) | LMNADRD2DRD3JAK2JAK3 | |
| SCHEMBL4341067 | 0.83 | RAB9A (0.46) | LMNASMN1; SMN2MAPK1MAPT | |
| SCHEMBL4341196 | 0.82 | MEN1 (0.49) | SMN1; SMN2MAPK1MAPT | |
| SCHEMBL4334635 | 0.82 | EGLN1 (0.39) | KDRCDK4CCNA2CCND1CDK2 | |
| SCHEMBL4333025 | 0.82 | ALDH1A1 (0.41) | KDRCDK4CCNA2CCND1CDK2 | |
| SCHEMBL4334432 | 0.81 | MEN1 (0.45) | LMNAEGLN1ROCK2SMN1; SMN2MAPK1 | |
| SCHEMBL2856935 | 0.81 | SMN1; SMN2 (0.54) | ROCK2SMN1; SMN2APEX1MAPTROCK1 | |
| SCHEMBL2864362 | 0.81 | GSK3B (0.44) | KDRCDK4CCNA2CCND1CDK2 | |
| SCHEMBL13635355 | 0.80 | KDM4E (0.42) | KDRCDK4CCNA2CCND1CDK2 | |
| SCHEMBL4332180 | 0.80 | ALDH1A1 (0.52) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |