Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375397 | 0.86 | KDM4E (0.68) | KDM4EHRH3ALDH1A1ACHETSHR | |
| SCHEMBL4375413 | 0.85 | KDM4E (0.67) | KDM4EHRH3ALDH1A1ACHETSHR | |
| SCHEMBL3774733 | 0.78 | KDM4E (0.57) | KDM4EHRH3EPHX2ALDH1A1ACHE | |
| SCHEMBL4380547 | 0.77 | ALDH1A1 (0.64) | KDM4EHRH3EPHX2ALDH1A1TSHR | |
| SCHEMBL2828800 | 0.77 | ACHE (0.67) | KDM4EHRH3MCHR1MCHR2ALDH1A1 | |
| SCHEMBL4375759 | 0.76 | ALDH1A1 (0.63) | KDM4EHRH3EPHX2ALDH1A1TSHR | |
| SCHEMBL4378928 | 0.72 | KDM4E (0.73) | KDM4EALDH1A1ACHEKMT2AORAI1 | |
| SCHEMBL4378521 | 0.71 | KDM4E (0.71) | KDM4EALDH1A1ACHETSHRKMT2A | |
| SCHEMBL3323667 | 0.70 | EPHX2 (0.59) | EPHX2 | |
| SCHEMBL3325414 | 0.70 | EPHX2 (0.59) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |