Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375397 | 0.90 | KDM4E (0.68) | ACHEHRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4375413 | 0.89 | KDM4E (0.67) | ACHECYP2D6CYP2C19NPSR1HRH3 | |
| SCHEMBL2836569 | 0.86 | ACHE (0.72) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| SCHEMBL2836399 | 0.85 | HRH3 (0.58) | ACHEHRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3774733 | 0.84 | KDM4E (0.57) | ACHEHRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2829771 | 0.84 | ACHE (0.73) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| SCHEMBL2829286 | 0.81 | ACHE (0.69) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| SCHEMBL182672 | 0.81 | ACHE (0.68) | ACHECYP2D6CYP2C19NPSR1KDM4E | |
| SCHEMBL656497 | 0.78 | TPSAB1 (0.70) | HRH3ALDH1A1POLBMAPTHPGD | |
| SCHEMBL15134818 | 0.78 | HRH3 (0.71) | HRH3ALDH1A1TP53TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |