Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382870 | 0.88 | KMT2A (0.54) | ALDH1A1SMN1; SMN2KMT2AGAAL3MBTL1 | |
| SCHEMBL2782099 | 0.70 | DRD2 (0.61) | ADRA2AADRA2BADRA2C | |
| SCHEMBL19030101 | 0.69 | TP53 (0.46) | ALDH1A1SMN1; SMN2KMT2AGAAL3MBTL1 | |
| SCHEMBL5061576 | 0.68 | POLB (0.55) | ALDH1A1SMN1; SMN2ADRA2AKMT2AL3MBTL1 | |
| SCHEMBL4380515 | 0.68 | KMT2A (0.60) | ALDH1A1SMN1; SMN2KMT2AGAAMEN1 | |
| SCHEMBL4383577 | 0.68 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2KMT2AL3MBTL1KDM4E | |
| SCHEMBL11179875 | 0.68 | HTR2C (0.47) | ALDH1A1SMN1; SMN2ADRA2AADRA2BADRA2C | |
| SCHEMBL4378935 | 0.67 | NPC1 (0.51) | ALDH1A1SMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL13603900 | 0.66 | TP53 (0.44) | ALDH1A1SMN1; SMN2KMT2AGAAL3MBTL1 | |
| SCHEMBL5486856 | 0.66 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2KMT2AGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |