SCHEMBL5486856

SCHEMBL5486856

O=C(O)N1CCN(CCCOc2cccc(Cl)c2Cl)CC1

nearest known ligand 0.69

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.69
SMN1; SMN2 Q16637 1/20 0.69
L3MBTL1 Q9Y468 3/20 0.65
KMT2A Q03164 2/20 0.65
GAA P10253 1/20 0.65
KDM4E B2RXH2 2/20 0.53
DRD2 P14416 6/20 0.50
HTR2A P28223 6/20 0.50
HTR1A P08908 5/20 0.50
CYP1A2 P05177 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C19 P33261 1/20 0.49
KCNA5 P22460 2/20 0.48
POLB P06746 1/20 0.46
MEN1 O00255 1/20 0.46
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5482274 0.90 L3MBTL1 (0.62) ALDH1A1SMN1; SMN2L3MBTL1KMT2AGAA
SCHEMBL5480360 0.85 POLB (0.58) ALDH1A1SMN1; SMN2L3MBTL1KMT2AGAA
SCHEMBL2176962 0.80 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2L3MBTL1KMT2AGAA
SCHEMBL5487159 0.80 TSHR (0.55) ALDH1A1SMN1; SMN2KMT2AGAAKDM4E
SCHEMBL5480294 0.80 HPGD (0.61) ALDH1A1SMN1; SMN2KMT2AGAAKDM4E
SCHEMBL20512386 0.78 POLB (0.48) ALDH1A1SMN1; SMN2L3MBTL1KMT2AKDM4E
SCHEMBL3985948 0.77 HRH3 (0.67) ALDH1A1SMN1; SMN2KMT2AKDM4ECYP2D6
SCHEMBL15349833 0.76 KDM4E (0.70) ALDH1A1SMN1; SMN2KMT2AKDM4EDRD2
SCHEMBL5481509 0.76 DRD2 (0.67) ALDH1A1L3MBTL1KMT2ADRD2HTR2A
SCHEMBL4288946 0.75 KDM4E (0.51) ALDH1A1SMN1; SMN2L3MBTL1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1720848-B1 DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS SANOFI AVENTIS (FR) 2007-12-05 EP claimed
EP-1720848-B1 DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS SANOFI AVENTIS (FR) 2007-12-05 EP disclosed
EP-1720848-A1 DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS Sanofi-Aventis (FR) 2006-11-15 EP disclosed
WO-2005090322-A1 DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2005-09-29 WO disclosed