Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | ME2 | P23368 | 2/20 | 0.53 |
| ▸ | ME1 | P48163 | 2/20 | 0.53 |
| ▸ | ME3 | Q16798 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375437 | 0.81 | KMT2A (0.72) | KMT2AGFERMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4379381 | 0.81 | TRPV1 (0.57) | MAPTKMT2AGFERMEN1CHRM1 | |
| SCHEMBL4375445 | 0.80 | HRH3 (0.60) | ME2ME1ME3MAPTKMT2A | |
| SCHEMBL9345400 | 0.80 | NPC1 (0.61) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13636226 | 0.79 | ME2 (0.50) | ROCK2ME2ME1ME3MAPT | |
| SCHEMBL4375389 | 0.79 | FKBP1A (0.65) | ME2ME1ME3MAPTKMT2A | |
| SCHEMBL9336419 | 0.79 | FKBP1A (0.64) | KMT2AALDH1A1NPSR1 | |
| SCHEMBL9346536 | 0.79 | IAPP (0.53) | ROCK2MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4380598 | 0.79 | ME2 (0.57) | ME2ME1ME3MAPTKMT2A | |
| SCHEMBL9350110 | 0.78 | NPC1 (0.59) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |