Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.40 |
| ▸ | TUBB | P07437 | 4/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426071 | 0.84 | ALDH1A1 (0.52) | ENPP2CA1CA2TUBB4ATUBB | |
| SCHEMBL3948200 | 0.81 | HPGD (0.41) | ENPP2TTRGABRA1GABRB2ALDH1A1 | |
| SCHEMBL23114 | 0.77 | ENPP2 (0.52) | ENPP2CA1CA2TUBB4ATUBB | |
| SCHEMBL31416596 | 0.74 | BACE1 (0.38) | ENPP2CA1CA2TUBB4ATUBB | |
| SCHEMBL28818319 | 0.74 | ALDH1A1 (0.42) | ENPP2CA1CA2TUBB4ATUBB | |
| SCHEMBL29427080 | 0.73 | ENPP2 (0.48) | ENPP2CA1CA2TUBB4ATUBB | |
| SCHEMBL23743 | 0.73 | ENPP2 (0.48) | ENPP2CA1CA2TUBB4ATUBB | |
| SCHEMBL3484229 | 0.73 | ALDH1A1 (0.48) | ENPP2CA1CA2TUBB4ATUBB | |
| SCHEMBL11040253 | 0.73 | TTR (0.47) | ENPP2CA1CA2TTRKDM4E | |
| SCHEMBL1792533 | 0.73 | CYP1A1 (0.61) | CA1CA2ALDH1A1JUNNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304385-B2 | Macrocyclic tetrazolyl hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| US-20090142299-A1 | MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2009-06-04 | — | — | US | disclosed |
| WO-2009064955-A1 | MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090142299-A1 | MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS | TMPRSS4, PRSS1, SPINT2 | ENPP2 1064/4885CA1 1521/4885CA2 2734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.