Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
| ▸ | CLK3 | P49761 | 1/20 | 0.47 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499153 | 0.77 | IDH1 (0.58) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL4199112 | 0.77 | DYRK1A (0.48) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL13171525 | 0.75 | L3MBTL1 (0.47) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL16695793 | 0.74 | IDH1 (0.59) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL12285521 | 0.72 | ABCG2 (0.83) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL29391519 | 0.72 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL2597652 | 0.72 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL13377736 | 0.71 | ABCG2 (0.61) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL5327318 | 0.70 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL14668902 | 0.70 | ABCG2 (0.78) | ALDH1A1KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622581-B2 | 6,7,8,9-substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2009-11-24 | — | — | US | disclosed |
| US-20070167434-A1 | 6,7,8,9-Substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC BVBA (BE) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167434-A1 | 6,7,8,9-Substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | HRH4, CBR1, HRH2 | ALDH1A1 1535/4885KDM4E 3958/4885MAPT 4876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.