Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | PPARD | Q03181 | 3/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440840 | 0.91 | PPARD (0.58) | PPARGPPARDFFAR1TDP1PPARA | |
| SCHEMBL13440566 | 0.90 | KDM4E (0.43) | PPARGPPARDFFAR1TDP1PPARA | |
| SCHEMBL3587102 | 0.84 | TDP1 (0.49) | PPARGPPARDFFAR1TDP1PPARA | |
| SCHEMBL13637150 | 0.84 | HPGD (0.44) | PPARGPPARDFFAR1TDP1PPARA | |
| SCHEMBL13637202 | 0.82 | LTB4R (0.41) | PPARGPPARDFFAR1TDP1PPARA | |
| SCHEMBL13637151 | 0.82 | PPARG (0.46) | PPARGPPARDFFAR1TDP1PPARA | |
| SCHEMBL13441633 | 0.82 | PPARG (0.46) | PPARGPPARDFFAR1TDP1PPARA | |
| SCHEMBL13441377 | 0.81 | PPARD (0.41) | PPARGPPARDTDP1PPARAALDH1A1 | |
| SCHEMBL3593824 | 0.79 | PPARG (0.51) | PPARGPPARDFFAR1TDP1PPARA | |
| SCHEMBL13637205 | 0.78 | PPARG (0.45) | PPARGPPARDPPARACYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |