Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 5/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440566 | 0.90 | KDM4E (0.43) | FFAR1PPARGPPARDPLA2G4BPPARA | |
| SCHEMBL13441377 | 0.86 | PPARD (0.41) | PPARGPPARDPTGDR2PPARAKDM4E | |
| SCHEMBL3576162 | 0.84 | LTB4R (0.48) | LTB4RLTB4R2FFAR1PPARGPPARD | |
| SCHEMBL13637205 | 0.83 | PPARG (0.45) | PPARGPPARDPPARAMAPT | |
| SCHEMBL13637152 | 0.82 | PPARG (0.45) | SMN1; SMN2FFAR1PPARGPPARDPTGDR2 | |
| SCHEMBL13637206 | 0.82 | LTB4R (0.45) | LTB4RLTB4R2SMN1; SMN2PPARGPPARD | |
| SCHEMBL3587335 | 0.81 | KDM4E (0.46) | LTB4RLTB4R2SMN1; SMN2FFAR1PPARD | |
| SCHEMBL13440840 | 0.81 | PPARD (0.58) | SMN1; SMN2FFAR1PPARGPPARDPPARA | |
| SCHEMBL3586956 | 0.76 | KDM4E (0.44) | LTB4RLTB4R2PPARGPPARDPPARA | |
| SCHEMBL13407823 | 0.76 | NPC1 (0.60) | LTB4RLTB4R2SMN1; SMN2PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |